Arterial spin labelling
Arterial spin labeling (ASL), also known as arterial spin tagging, is a
Physics
Arterial spin labeling utilizes the water molecules circulating with the brain, and using a radiofrequency pulse, tracks the blood water as it circulates throughout the brain. After a period of time in microseconds (enough to allow the blood to circulate through the brain), a 'label' image is captured. A 'control' image is also acquired before the labeling of the blood water. A subtraction technique gives a measurement of perfusion. In order to increase
One study has shown that although there are voxel differences when different readout methods are used, average gray matter CBF are still comparable. Differences in SNR are apparent when each voxel compared, but collectively are negligible.
Continuous arterial spin labelling
In continuous arterial spin labeling (CASL), the blood water is inverted as it flows through the brain in one plane. CASL is characterized by one single long pulse (around 1–3) seconds. This may be disadvantageous for certain scanners that are not designed to maintain a radiofrequency pulse that long, and therefore would require adjustments to a
Pulsed arterial spin labelling
In pulse arterial spin labeling (PASL), blood water is inverted as it passes through a labeling slab (of 15 to 20 cm) instead of a plane. There are different variations of this implementations, including EPISTAR and PICORE and PULSAR. Most scanners have been designed to have PASL work out-of-the-box for research use.
Velocity selective arterial spin labelling
Velocity selective arterial spin labeling is a strategy that still requires validation. Velocity selective arterial spin labeling is advantageous in a population where blood flow may be impeded (e.g. stroke), because the labeling occurs closer to the capillaries. This allows the post labeling decay to be shorter.[9]
Diffusion prepared pseudocontinuous arterial spin labelling (DP-pCASL)
Diffusion-prepared pseudocontinuous ASL (DP-pCASL) is a more recent ASL variant sequence that magnetically labels water molecules and measures their movement across the blood-brain barrier complex, which allows for the calculation of the water exchange rate (kw).[10][11] kw is used as a surrogate for BBB function and permeability. Water exchange across the BBB is mediated by a number of processes, including passive diffusion, active co-transport through the endothelial membrane, and predominantly by facilitated diffusion through the dedicated water channel aquaporin-4 (AQP4). Several studies have investigated the use of DP-pCASL in cerebrovascular diseases, including acute ischemic stroke,[12] CADASIL,[13] hereditary cerebral small vessel disease [14] as well as in animal models.[15]
Analysis of ASL images
ASL maps can mainly be analyzed using the same tools to analyze
ASL
Comparison with fMRI
Clinical use
In
Although the primary form of
There have been research to apply ASL to renal imaging,[24] pancreas imaging,[25] and placenta imaging. A challenge to these sort of non-cerebral perfusion is motion due to breathing. Additionally, there is a lot less development on the segmentation of theses specific organs, so the studies are relatively small scale.
Safety
ASL is in general a safe technique, although injuries may occur as a result of failed safety procedures or human error like other MRI techniques.[26]
ASL, like other MRI modalities generate a fair amount of acoustic noise during the scan, so earplugs are advised.
References
- ^ Fortin F, Gaillard F. "Arterial spin labelling (ASL) MR perfusion". Radiopaedia. Retrieved 2017-10-15.
- ^ "Arterial spin labeling". University of Michigan. Retrieved 2017-10-27.
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- ^ Leigh, J.S., Detre, J.A., Williams, D.S., Koretsky, A.P. "Methods for measuring perfusion using magnetic resonance imaging" US Patent No. 5,402,785 (1995).
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External links
- mriquestions.com [1]