Gregg L. Semenza
Gregg L. Semenza | |
---|---|
Hypoxia-inducible factors | |
Spouse | Laura Kasch-Semenza |
Awards | Albert Lasker Award for Basic Medical Research (2016) Nobel Prize in Physiology or Medicine (2019) |
Scientific career | |
Institutions | Johns Hopkins School of Medicine |
Thesis | Molecular genetic analysis of the silent carrier of beta thalassemia (haplotype) (1984) |
Doctoral advisors | Elias Schwartz Saul Surrey |
Gregg Leonard Semenza (born July 12, 1956) is a pediatrician and Professor of Genetic Medicine at the
Early life
Semenza was born on July 12, 1956,[6] in Flushing, New York City; he and his four siblings grew up in Westchester County, New York.[7]
Education and career
Semenza grew up in
Research
While a post-doctorate researcher at Johns Hopkins, Semenza evaluated gene expression in
Semenza's research overlapped with that of
Retractions
In 2011 Semenza retracted from Biochemical Journal one paper coauthored with Naoki Mori (and other collaborators), and in 2022 retracted four papers from PNAS according to Retraction Watch.[13] As of 2022, concerns about the integrity of images in 52 articles coauthored by Semenza have been raised on PubPeer. This has led to investigations by the journals where these articles appeared, resulting in many corrections, retractions and expressions of concern.[14]
In 2023, additional papers in PNAS[15] and Oncogene[16] were retracted.
As of 2023, Semenza has had 10 of his research papers retracted due to data falsification via improper manipulation and/or duplication of images.[17][18][19]
Personal life
Semenza is married to Laura Kasch-Semenza, whom he had met while at Johns Hopkins, and who currently operates one of the university's genotyping facilities.[7]
Awards
- 1989: Lucille P. Markey Scholar Award in Biomedical Science, Markey Trust[20]
- 1995: Elected Member of the American Society for Clinical Investigation[21]
- 2000: E. Mead Johnson Award for Research in Pediatrics, Society for Pediatric Research[22]
- 2008: Elected Member of the National Academy of Sciences[23]
- 2008: Elected Member of the Association of American Physicians[24][20]
- 2010: Gairdner Foundation International Award[25]
- 2012: Elected to the Institute of Medicine[26]
- 2012: The Scientific Grand Prize of the Lefoulon-Delalande Foundation[27]
- 2012: Stanley J. Korsmeyer Award, American Society for Clinical Investigation[28]
- 2014: Wiley Prize[29]
- 2016:
- 2019: William Kaelin and Peter J. Ratcliffe), awarded by the Nobel Prize committee "for their discoveries of how cells sense and adapt to oxygen availability."[4][31][32]
References
- ^ "Gregg L. Semenza, M.D., Ph.D."
- ^ Foundation, Lasker. "Oxygen sensing – an essential process for survival – The Lasker Foundation". The Lasker Foundation.
- ^ "The Nobel Prize in Physiology or Medicine 2019". NobelPrize.org. Retrieved October 7, 2019.
- ^ a b Kolata, Gina; Specia, Megan (October 7, 2019). "Nobel Prize in Medicine Awarded for Research on How Cells Manage Oxygen – The prize was awarded to William G. Kaelin Jr., Peter J. Ratcliffe and Gregg L. Semenza for discoveries about how cells sense and adapt to oxygen availability". The New York Times. Retrieved October 8, 2019.
- ^ Kincaid, Author Ellie (October 2, 2023). "Nobel Prize winner Gregg Semenza tallies tenth retraction". Retraction Watch. Retrieved February 15, 2024.
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has generic name (help) - ^ "Gregg L. Semenza: Facts". nobelprize.org. Retrieved October 9, 2019.
- ^ PMID 20679204.
- ^ "Johns Hopkins geneticist Gregg Semenza wins Lasker Award for insights into how cells sense oxygen". September 13, 2016.
- OCLC 1049531609 – via ProQuest.
- ^ "Gairdner Award". October 7, 2019.
- ^ erythrocyteproduction [...] During the same time period in which Semenza was developing EPO-transgenic mice, Peter Ratcliffe, a physician and kidney specialist, was establishing a laboratory in Oxford University's Nuffield Department of Medicine to study the regulation of EPO
- PMID 31595071.
- ^ "Nobel Prize winner Gregg Semenza retracts four papers". Retraction Watch. September 3, 2022.
- S2CID 253063290.
- PMID 37099630.
- PMID 37221224.
- ^ Ellie Kincaid (October 2, 2023). "Nobel Prize winner Gregg Semenza tallies tenth retraction". Retraction Watch. Retrieved October 21, 2023.
- ^ "Retraction Watch Database". Retraction Watch. Center for Scientific Integrity. Retrieved November 7, 2023.
- ^ "Nobel Prize winner Gregg Semenza retracts another study". Chemical & Engineering News. Retrieved November 7, 2023.
- ^ a b "Gregg L. Semenza, M.D., Ph.D." Johns Hopkins Medicine. Retrieved October 8, 2019.
- ^ "Gregg L. Semenza, MD, PhD". American Society for Clinical Investigation. Retrieved October 7, 2019.
- ^ "E. Mead Johnson Award in Pediatric Research". Archived version of American Pediatric Society website. Archived from the original on December 15, 2014. Retrieved October 7, 2019.
- ^ "72 New Members Chosen By Academy". nationalacademies.org. Retrieved October 7, 2019.
- ^ "2008 Elected Members". Association of American Physicians. December 20, 2019. Archived from the original on December 20, 2008. Retrieved October 8, 2019.
- ^ "Nobel Prize in Physiology or Medicine awarded to 2010 Gairdner Laureates". gairdner.org. October 7, 2019. Retrieved October 7, 2019.
- ^ "Two NAM Members Receive Albert Lasker Basic Medical Research Award". nam.edu. September 15, 2016. Retrieved October 7, 2019.
- ^ "Gregg L. Semenza". Institut de France. Grands Prix des Fondations. April 21, 2015. Retrieved December 12, 2017.
- ^ "The 2012 Stanley J. Korsmeyer Award: William G. Kaelin, Jr., MD, and Gregg L. Semenza, MD, PhD". www.the-asci.org. Archived from the original on August 15, 2017. Retrieved October 7, 2019.
- ^ "Wiley: The 13th Annual Wiley Prize in Biomedical Sciences Awarded for Advancements in Oxygen Sensing Systems". www.wiley.com. Retrieved October 7, 2019.
- ^ Foundation, Lasker. "Oxygen sensing – an essential process for survival". The Lasker Foundation. Retrieved October 7, 2019.
- ^ Gallagher, James (October 7, 2019). "How cells sense oxygen wins Nobel prize". Retrieved October 7, 2019.
- ^ "The Nobel Prize in Physiology or Medicine 2019". NobelPrize.org. Retrieved October 8, 2019.
External links
- Gregg L. Semenza on Nobelprize.org including the Nobel Lecture on 7 December 2019 Hypoxia-Inducible Factors in Physiology and Medicine